We specialize in high quality monoclonal antibodies, particularly those which are difficult to produce. Our two main foci are robust screening methodologies and excellent antigen design.
Fusion Antibodies typically specialise in designing non-standard projects for difficult to produce antibodies and achieve this by carefully designing our screening strategies. For example; we have designed strategies for generating antibodies to differentiate between phosphorylated and non-phosphorylated forms of a protein and strategies to generate non-interacting pairs of antibodies against the same protein.
We can also run simple projects for more straight forward targets.
Using techniques developed over 15 years, our lab achieves high fusion success rates which increases the likelihood of a successful outcome of your project. Over the past 15 years we have performed more than 250 hybridoma fusions and produced over 1000 hybridoma cell lines for a wide range of clients, from small biotech to large pharmaceutical companies. We offer a range of options for developing monoclonal antibodies. Our goal is to allow access to the production of high quality antibodies to a wide variety of researchers with flexible pricing. We provide a “core” service including immunization of mice, hybridoma fusion, screening and cloning but now also have options to include additional services such as adaptation to supplement free media.
We use 3D modelling software to assist us in designing high quality peptide antigens to represent your protein of interest. This allows us to develop high quality peptides which we know are accessible on the protein surface and immunogenic. We also model and overlay these peptide sequences to make sure they are conformationally similar to the target protein. The result is an immunogen which accurately represents the intended target and therefore better antibodies with higher affinities. Our custom antibody production service is based on the classic Kohler and Milstein technique for the production of monoclonal antibodies becuase we believe it the best technique for high quality monoclonals.
Our approach is to listen to your final requirements and work with you to design a mile-stoned work package to deliver on your exact requirements for your monoclonal antibody development program. The murine antibodies we manufacture are perfect as high quality research antibodies and when your project is ready we can humanize them for use in the clinic.
Fusion Antibodies are experts at monoclonal antibody generation and pride ourselves on the following key points:
We have designed techniques for generating antibodies to differentiate between phosphorylated and non-phosphorylated forms of a protein, strategies to generate non-interacting pairs of antibodies against the same protein and methods for targeting highly specific epitopes on the target. We can also run simple projects for more straight forward targets.
For more information contact us on the form below, email firstname.lastname@example.org or call UK +44 (0)28 9043 2800
Fusion Antibodies are experts at Antibody Sequencing, with over 15 years or experience and 700 antibodies successfully sequenced we are number 1 in the world for quality and expertise.
We provide mAb Humanization as a royalty free service. 15+ years experience in the antibody development industry and our CDRx™ platform enables a robust, reliable and accurate modernized version of the CDR grafting technique.
Feel free to get in touch for any further information. We would love to hear from you.Contact Us