Antibody Developability

Antibody Developability

We will optimize your sequence to deliver a therapeutic antibody that is safe, stable and commercially scalable.

Antibody Developability by Design

Different antibody attributes can impact the safety, efficacy and manufacturability of your biologic drug and it is important to understand these as early as possible in the drug discovery process.  We begin every project with the end in mind and use our expertise in sequence optimization to help accelerate your development program into the clinic.

Fusion Antibodies can assess and optimize the developability profile of your antibody at the earliest stages to deliver the best possible antibody sequence. With years of experience in antibody engineering and manufacturing cell line development, Fusion Antibodies understand what it takes to deliver the optimal antibody sequence.  We provide cost-effective solutions to mitigate risk throughout your antibody development program, offering the best chances of success in the clinic.

Antibody Developability

Individual in vitro biophysical characterization analyses

We offer a full menu of individual in vitro analyses to assess/ profile the function and biophysical characteristics of your molecule.

In silico antibody developability analysis package

We offer an in silico analysis package that profiles the primary sequence and tertiary structure of your protein to investigate potential developability liabilities. This includes potential charge variant sites, T cell epitopes, N-linked glycosylation sites, hydrophobicity and ropensity for aggregation.

This package is useful for aiding lead and candidate selection during the drug discovery process.

Antibody developability consultancy package

We offer a consultancy package including in silico primary sequence and tertiary structure profiling of your molecule followed by a detailed optimization proposal to improve the developability profile. All designed variants will be modelled and analyzed in silico to support our recommendations. This can be extended to a tailored package including production and in vitro analysis of designed variants to support the optimization program and aid in selection of a lead candidate for development.

Tailored optimization package

We offer a full range of tailored packages including in silico and in vitro profiling of protein variants to improve the developability profile of your protein. This includes reduction in propensity for aggregation, removal of T cell epitopes, CDR germlining, removal of charge variants and more.

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